減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1018Please respect copyright.ＰＥＮＡＮＡHJWFHZuqsE
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一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1018Please respect copyright.ＰＥＮＡＮＡENez9i17bN
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1018Please respect copyright.ＰＥＮＡＮＡVPmKplGb9e
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(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1018Please respect copyright.ＰＥＮＡＮＡSGeg0bp7by
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1018Please respect copyright.ＰＥＮＡＮＡOYg1VtPxI4
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1018Please respect copyright.ＰＥＮＡＮＡ6wuU0id44o
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相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1018Please respect copyright.ＰＥＮＡＮＡjNg31PfdpE
1018Please respect copyright.ＰＥＮＡＮＡiIHnVQhULP
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1018Please respect copyright.ＰＥＮＡＮＡ3WF1y9FYvj
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1018Please respect copyright.ＰＥＮＡＮＡeOkZSZjc7b
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(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1018Please respect copyright.ＰＥＮＡＮＡcztTmExHxU
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第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1018Please respect copyright.ＰＥＮＡＮＡs51FoSiau0
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而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1018Please respect copyright.ＰＥＮＡＮＡUxlYrb3xLE
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1018Please respect copyright.ＰＥＮＡＮＡX1HVvHfM2e
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1018Please respect copyright.ＰＥＮＡＮＡrNzMdIqUOb
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1018Please respect copyright.ＰＥＮＡＮＡeqGcnCRMsh
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Link:1018Please respect copyright.ＰＥＮＡＮＡ2KEC5VI90v
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1018Please respect copyright.ＰＥＮＡＮＡaNWTEwoWho
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1018Please respect copyright.ＰＥＮＡＮＡ4gcmI3Nnv4
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Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1018Please respect copyright.ＰＥＮＡＮＡS2vSiyjlE2
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661018Please respect copyright.ＰＥＮＡＮＡbP0Hk3krU7
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1018Please respect copyright.ＰＥＮＡＮＡf4TEohIzyx
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1018Please respect copyright.ＰＥＮＡＮＡLldSNx3K09
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1018Please respect copyright.ＰＥＮＡＮＡc8YJbhtJ64
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