腫瘤內有一小部份的細胞被稱之為Cancer Stem Cells(CSC)，他們對於腫瘤的發展有著莫大的功用。531Please respect copyright.ＰＥＮＡＮＡGz4lSsvD0K
531Please respect copyright.ＰＥＮＡＮＡdGnOCcr6Ww
化療過後，大部份的癌細胞均會被殲滅，而很多時候只剩下這些CSC能夠生存；531Please respect copyright.ＰＥＮＡＮＡUyz2AUaJQX
學術界大多數會稱呼這現象為Minimal Residual Disease。531Please respect copyright.ＰＥＮＡＮＡIUHspsbznW
531Please respect copyright.ＰＥＮＡＮＡiWsW58OFTH
這些一息尚存的CSC會在某一刻再度發展出新的腫瘤，而與之前腫瘤不同的是，他們會展現出抗藥性，較早前所用的化療藥物再不會對他們見效。531Please respect copyright.ＰＥＮＡＮＡcjB6CDeuur
531Please respect copyright.ＰＥＮＡＮＡWOrU0gVLQK
正因如此，現今有不少針對CSC研究一直進行中，希望可以找出辦法消滅這些CSC。531Please respect copyright.ＰＥＮＡＮＡTmoiYtbJ4g
531Please respect copyright.ＰＥＮＡＮＡOPp6mFItY8
531Please respect copyright.ＰＥＮＡＮＡsL46s3Wr91
（圖2）CSC之所以非常之難消滅，原因就是他有各式各樣的機制躲避化療追擊，如陳同佳這天下大仆街一樣詭計多端。531Please respect copyright.ＰＥＮＡＮＡEPY4FfXkua
531Please respect copyright.ＰＥＮＡＮＡuQtKNErY1P
531Please respect copyright.ＰＥＮＡＮＡEe7FLYgRyx
其中一例就是CSC會產生名為ABCG2的蛋白質，這些ABCG2蛋白質有著將化療藥物排出細胞體外的效果，導致化療藥物無法長期留在細胞內，大幅度失去藥效。531Please respect copyright.ＰＥＮＡＮＡNOMa1JMQYD
531Please respect copyright.ＰＥＮＡＮＡdUJfZylA8L
（圖3）有科學家發現（Ref1)，名為SMAR1蛋白質有抑制ABCG2產生的功效。亦即是說，SMAR1蛋白質含量越低的話，ABCG2就越容易能夠生產出來。531Please respect copyright.ＰＥＮＡＮＡD4Za6jbnWf
531Please respect copyright.ＰＥＮＡＮＡEwLVT2D9fn
531Please respect copyright.ＰＥＮＡＮＡqg9fDasErr
531Please respect copyright.ＰＥＮＡＮＡD4XUy8KNMe
531Please respect copyright.ＰＥＮＡＮＡNalKB4lJZF
而CSC內有兩隻名為OCT4及SOX2的蛋白質，他們能夠抑制SMAR1的蛋白質產生，導致ABCG2更容易產生出來，令細胞更容易將藥物排出體外。531Please respect copyright.ＰＥＮＡＮＡtCw42XkLE2
531Please respect copyright.ＰＥＮＡＮＡZXxb1z2Udr
531Please respect copyright.ＰＥＮＡＮＡ31NT32DgiC
（圖4）尋覓已知資料一輪後，阿斯匹靈為已證實可抑制OCT4及SOX2蛋白質的藥物，同時亦不會被ABCG2有效排出。531Please respect copyright.ＰＥＮＡＮＡv8wTqqkQjc
531Please respect copyright.ＰＥＮＡＮＡISzypaBYWe
531Please respect copyright.ＰＥＮＡＮＡSdPzqxqJCe
這裡無疑會產生一道詢問，若果利用阿斯匹靈抑制ABCG2的產生，同時再加上化療藥物的話，會否是殺死CSC的一道妙計呢?531Please respect copyright.ＰＥＮＡＮＡVJv5K3wRC7
531Please respect copyright.ＰＥＮＡＮＡR1FFshHWN7
531Please respect copyright.ＰＥＮＡＮＡ61NtOZza2H
（圖5）在老鼠實驗中，同時用上阿斯匹靈及化療藥物Doxorubicin的話，的確可以令腫瘤大幅度縮小。531Please respect copyright.ＰＥＮＡＮＡboWHsMjHrp
531Please respect copyright.ＰＥＮＡＮＡ1XOnV4ozgy
531Please respect copyright.ＰＥＮＡＮＡqB1rbQcq7D
但在這實驗中，單獨用上阿斯匹靈已能導致腫瘤縮小，而且文章亦沒有確實證據指出腫瘤縮小的原因是否因為少了CSC的緣故。531Please respect copyright.ＰＥＮＡＮＡ0eQ27ffnD8
531Please respect copyright.ＰＥＮＡＮＡAHsMdaosL6
雖有理論證據在背後支持，但用上阿斯匹靈輔助化療效果的理論還需要確實的實驗結果再作進一步的證實。531Please respect copyright.ＰＥＮＡＮＡ4bpLzrxzDc
531Please respect copyright.ＰＥＮＡＮＡvZuPYopvwt
531Please respect copyright.ＰＥＮＡＮＡvCWZnbCvSM
到底阿斯匹靈輔助化療效果的理論得以確實先，還是陳同住到台灣自首先呢？531Please respect copyright.ＰＥＮＡＮＡ0k5NWsW7wI
531Please respect copyright.ＰＥＮＡＮＡYYsTnbs3vO
答案呼之欲出！531Please respect copyright.ＰＥＮＡＮＡzjRKRnuayb
531Please respect copyright.ＰＥＮＡＮＡmPfqSBGlwg
531Please respect copyright.ＰＥＮＡＮＡPvmDurnOGl
531Please respect copyright.ＰＥＮＡＮＡ5kdBm6EbXt
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。531Please respect copyright.ＰＥＮＡＮＡOzQgICSc2z
531Please respect copyright.ＰＥＮＡＮＡRaTOP5TpZA
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc531Please respect copyright.ＰＥＮＡＮＡ8uGWJlvNop
531Please respect copyright.ＰＥＮＡＮＡmVOaX0mkvM
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。531Please respect copyright.ＰＥＮＡＮＡP5h7r40l8C
531Please respect copyright.ＰＥＮＡＮＡgPljBPAejG
Link:531Please respect copyright.ＰＥＮＡＮＡGj8Z3lvOwB
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio531Please respect copyright.ＰＥＮＡＮＡat5RTxJZBZ
531Please respect copyright.ＰＥＮＡＮＡkjQ5TclFqF
531Please respect copyright.ＰＥＮＡＮＡ5CUxRl4pRA
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。531Please respect copyright.ＰＥＮＡＮＡ7QgYZIBHpY
531Please respect copyright.ＰＥＮＡＮＡTCWWFwXRB0
https://www.instagram.com/potatopigtongue/531Please respect copyright.ＰＥＮＡＮＡbUi5Jfjfpb
531Please respect copyright.ＰＥＮＡＮＡdVlcQhnqNq
Ref1:https://stke.sciencemag.org/content/13/654/eaay6077531Please respect copyright.ＰＥＮＡＮＡUXd5RAOAY9
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
