黃金葡萄球菌這字眼,周不時亦會在新聞媒體聽得到。707Please respect copyright.PENANA15aPwvqhd5707Please respect copyright.PENANACvOnxQFlMc
707Please respect copyright.PENANAI4QeiAyFWx
它之所以被冠以黃金這稱號,是因為它能夠製造大量金黃色的葡萄球菌黃素 (Staphyloxanthin),以及微量黃色化合物4,4‘-Diaponeurosporene。707Please respect copyright.PENANAGPDpQZBgDp
707Please respect copyright.PENANAzArNJvkl5w
(圖2)當細菌入侵腸道的時候,我們的腸道內壁細胞及前來救駕的免疫細胞會釋出微量雙氧水等的游離基(Reactive oxygen species),對細菌進行攻擊。707Please respect copyright.PENANA5qMu1pIH9u707Please respect copyright.PENANAUv4sCdOgKW
707Please respect copyright.PENANAqWDihWXtKe
但黃金葡萄球菌的金黃色葡萄球菌黃素及另外那種黃色化學物正是能夠中和游離基攻擊的色素,因此免疫系統所產生的游離基攻擊對它傷害不大。707Please respect copyright.PENANAfL4vSGhQRy
707Please respect copyright.PENANALFmpUsx0R9
然而,如果刪去製作色素的蛋白酶,「黃金」葡萄球菌失去抵擋游離基的手段,對宿主的感染力亦因而大大減低。707Please respect copyright.PENANAwibSmRrvep
707Please respect copyright.PENANAy5F89UjvXd
(圖3)同時間,若將負責製造黃色色素的蛋白酶從黃金葡萄球菌轉移到另一款葡萄球菌,獲得了色素製作能力的它在老鼠身上所造成的感染傷害亦更之為強,引證色素對於細菌感染力的重要性。707Please respect copyright.PENANAnI0LFzmgWT707Please respect copyright.PENANAfV1STGPDkq
707Please respect copyright.PENANAM7ccrjb5gM
(圖4)再舉另外一道例子,Cryptococcus neoformans是一種真菌(fungus),707Please respect copyright.PENANA0YlmKCBlzW
它能夠製作黑色素(Melanin),亦即是上集所談及決定髮膚眼色的色素。707Please respect copyright.PENANAJvDnXxJroK707Please respect copyright.PENANA8szH6W5ctC
707Please respect copyright.PENANA01p280tAi1
黑色素除了跟金黃色葡萄球菌黃素一樣能夠抵擋游離基的攻擊外,其本身帶有負極的性質更能與兩隻帶有正極的常用抗真菌素(amphotericin B 及 caspofungin)結合,大大削弱藥物傷害真菌的能力。707Please respect copyright.PENANAggqL3mF9hc
707Please respect copyright.PENANA6oCHmjQwtB
707Please respect copyright.PENANARCybYxPPnL
延伸閱讀:707Please respect copyright.PENANALDukQq6yXi
深入淺出–從深海生物中發掘出抗真菌藥物707Please respect copyright.PENANAUqzYTh9Efd
- 分享自 LIHKG 討論區707Please respect copyright.PENANAy6NATFiCjz
https://lih.kg/2296185707Please respect copyright.PENANARQaM9TEvrE
707Please respect copyright.PENANAneRBOQZWND
707Please respect copyright.PENANAy1I6kFkDe1
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。707Please respect copyright.PENANA5L6vNxZMxG
707Please respect copyright.PENANA9m33mKwuwC
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc707Please respect copyright.PENANAUQC0FuQE3V
707Please respect copyright.PENANAZdb51qymMh
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。707Please respect copyright.PENANA4ULFpbedYy
707Please respect copyright.PENANAMz2jTYG5df
Link:707Please respect copyright.PENANAxLunodw8fY
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio707Please respect copyright.PENANApbIazCao2Y
707Please respect copyright.PENANAqKVQw7vIAr
707Please respect copyright.PENANANFpRxgvDIx
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。707Please respect copyright.PENANAv7cdJsYOx5
707Please respect copyright.PENANAL1Xpz9coVk
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743764/707Please respect copyright.PENANAleAeUyQr3Z