減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1027Please respect copyright.ＰＥＮＡＮＡ4Zrtjn4eg8
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一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1027Please respect copyright.ＰＥＮＡＮＡVXurBJvXC5
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1027Please respect copyright.ＰＥＮＡＮＡoF1UkuJtQY
1027Please respect copyright.ＰＥＮＡＮＡOiiLgpkCTR
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(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1027Please respect copyright.ＰＥＮＡＮＡ1jDZ9MAmPy
1027Please respect copyright.ＰＥＮＡＮＡ3DAj2o1RMn
1027Please respect copyright.ＰＥＮＡＮＡyRINFdvMz4
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1027Please respect copyright.ＰＥＮＡＮＡv2W5jUDBYM
1027Please respect copyright.ＰＥＮＡＮＡRZDxALUUc3
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1027Please respect copyright.ＰＥＮＡＮＡBZwOV1HUVK
1027Please respect copyright.ＰＥＮＡＮＡ30ydtVeP8k
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1027Please respect copyright.ＰＥＮＡＮＡbAve4ZUYPZ
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1027Please respect copyright.ＰＥＮＡＮＡOtfz4Am7tv
1027Please respect copyright.ＰＥＮＡＮＡp3E72Bi3bR
1027Please respect copyright.ＰＥＮＡＮＡo9KYNPC2c7
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1027Please respect copyright.ＰＥＮＡＮＡOtegfofEVg
1027Please respect copyright.ＰＥＮＡＮＡwgXpKXo7RW
1027Please respect copyright.ＰＥＮＡＮＡSC8JSuT5mz
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1027Please respect copyright.ＰＥＮＡＮＡDd2LVQUsPo
1027Please respect copyright.ＰＥＮＡＮＡTaOMrJVVZS
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1027Please respect copyright.ＰＥＮＡＮＡ32OntB6HgI
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1027Please respect copyright.ＰＥＮＡＮＡRi9DFLEjpX
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1027Please respect copyright.ＰＥＮＡＮＡydvLJFnzTp
1027Please respect copyright.ＰＥＮＡＮＡh2dI9yQlRl
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1027Please respect copyright.ＰＥＮＡＮＡKgAAgsxM9h
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Link:1027Please respect copyright.ＰＥＮＡＮＡth5yb6EDwR
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1027Please respect copyright.ＰＥＮＡＮＡ9I5QtH4vqj
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1027Please respect copyright.ＰＥＮＡＮＡCJf6cdUv2j
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Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1027Please respect copyright.ＰＥＮＡＮＡk4GJnOtF5H
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661027Please respect copyright.ＰＥＮＡＮＡy1slu6LKlJ
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1027Please respect copyright.ＰＥＮＡＮＡUV6IAIeN2l
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1027Please respect copyright.ＰＥＮＡＮＡ84KcJWgwSO
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1027Please respect copyright.ＰＥＮＡＮＡbmRKRZPIBt
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