減肥是不少女性、又或者亦是男性的終身使命。985Please respect copyright.ＰＥＮＡＮＡBXVAREh0hP
先天上，兩性在儲存脂肪及體脂分佈上均有非常不同的地方。985Please respect copyright.ＰＥＮＡＮＡmzmGy2BPoO
985Please respect copyright.ＰＥＮＡＮＡV9INX1AW03
985Please respect copyright.ＰＥＮＡＮＡEGYsB1Erzp
985Please respect copyright.ＰＥＮＡＮＡPLFs4negel
（圖1）已知的知識中，荷爾蒙及性別染色體在脂肪控制上均扮演著舉足輕重的角色。985Please respect copyright.ＰＥＮＡＮＡ8L6x6WCeVW
985Please respect copyright.ＰＥＮＡＮＡNn0oVsi0Pa
普遍來說，女性傾向把脂肪儲存在臀部，而更年期的女性及男性則傾向把脂肪儲存在肚部。985Please respect copyright.ＰＥＮＡＮＡeI0QbyFu1O
985Please respect copyright.ＰＥＮＡＮＡp9IEKCCfF4
增加更年期女性的體內雌激素濃度的話，將能減低脂肪儲存在肚部的傾向，間接證明荷爾蒙對於體脂分佈的影響性。985Please respect copyright.ＰＥＮＡＮＡ30JFVwfFAO
985Please respect copyright.ＰＥＮＡＮＡqdSIY11Ubs
然而，性別荷爾蒙在青春期發育的時候最為旺盛，但男女性的人體嬰兒及老鼠在發育之前，體脂的分佈亦已有所不同。985Please respect copyright.ＰＥＮＡＮＡH8vSKg4NFM
而且，XXY的男性比XY的男性，體脂相對為多。985Please respect copyright.ＰＥＮＡＮＡ5DPxO4q88E
985Please respect copyright.ＰＥＮＡＮＡQe3s9qj6oV
這亦暗示性別染色體在脂肪控制上亦扮演著一定的角色。985Please respect copyright.ＰＥＮＡＮＡnvkOwTtONK
985Please respect copyright.ＰＥＮＡＮＡy5KC1ApI6p
而近日就有科學家發表文章（Ref1)，解構X染色體導致脂肪相對上較容易增加的原因。985Please respect copyright.ＰＥＮＡＮＡ2UitsoUA3N
985Please respect copyright.ＰＥＮＡＮＡb8OwXWObTb
985Please respect copyright.ＰＥＮＡＮＡlBwVWLtYBe
985Please respect copyright.ＰＥＮＡＮＡBUsvUfFSrd
（圖2）X染色體主宰超過800種蛋白質的產生。我們的身體有一道名為X inactivation的機制，使其中一條X染色體不能正常運作，好使蛋白質不會以雙倍的方式產生，造就男性及女性相關於X染色體所產生的蛋白質水平不會有太大的差異；985Please respect copyright.ＰＥＮＡＮＡMeDeHctC34
男性只有一條X染色體，而X inactivation亦不會發生。985Please respect copyright.ＰＥＮＡＮＡPgh2eKeoyh
985Please respect copyright.ＰＥＮＡＮＡESNg7l6xHG
985Please respect copyright.ＰＥＮＡＮＡKIRvvZ6Ivg
但有時候，有一些X chromosome區域並沒有被抑制下來，造就女性身上某些蛋白質的數量會比男性為高。985Please respect copyright.ＰＥＮＡＮＡtToba9Zkig
985Please respect copyright.ＰＥＮＡＮＡ6mIpYAzui7
而現今發現，有至少四種蛋白質普遍上並沒有被X inactivation機制抑制下來。985Please respect copyright.ＰＥＮＡＮＡsN4iZ7wYSt
985Please respect copyright.ＰＥＮＡＮＡG73ntZ8eyO
985Please respect copyright.ＰＥＮＡＮＡZdVHAwwrpj
985Please respect copyright.ＰＥＮＡＮＡp3wlNtS6u3
985Please respect copyright.ＰＥＮＡＮＡwWiK1IK8qe
985Please respect copyright.ＰＥＮＡＮＡHgWnaXV9l8
（圖3）Kdm5c就是其中一隻沒有被抑制下來的蛋白質，它是一種histone deacetylase，簡單來說就是有著控制基因上那一些蛋白質能夠產生出來，那一些不能產生出來的權力。985Please respect copyright.ＰＥＮＡＮＡUWMPtebTOU
985Please respect copyright.ＰＥＮＡＮＡ85ay82eNFt
科學家用上不同的實驗證實，Kdm5c有著控制幹細胞較容易變成為脂肪細胞的功能。985Please respect copyright.ＰＥＮＡＮＡ0UlvYu6QUl
985Please respect copyright.ＰＥＮＡＮＡ9qBaydeU8G
在老鼠上，Kdm5c數量的多少，對於進食的數量並沒有太大的變化，但Kedm5c數量較多的老鼠身上則有著更多的脂肪。985Please respect copyright.ＰＥＮＡＮＡK4TEspNx1R
985Please respect copyright.ＰＥＮＡＮＡLW4AFa0n4T
而對比七百多名孖生女性體內Kdm5c數量及其BMI的話，亦能發現有著正比的關係。985Please respect copyright.ＰＥＮＡＮＡeJlzqWJsws
985Please respect copyright.ＰＥＮＡＮＡ8UWOxdzDQm
女士先天上較易產生更多的脂肪，將有助懷孕的時候給予嬰兒更多的保護及營養需要。985Please respect copyright.ＰＥＮＡＮＡ4yh76bE6Bj
而Kdm5c這蛋白質是否為此先天性上而設，暫時還沒有決定性的實驗能夠證實。985Please respect copyright.ＰＥＮＡＮＡJq38tCG3E2
985Please respect copyright.ＰＥＮＡＮＡQ6WYncBL9r
至於能否利用基因技術或者藥物來抑制Kdm5c的數量或功效而達至減肥功效，暫時亦沒有任何的數據，而且Kdm5c顯然不只是局限於影響脂肪新陳代謝這一方面，隨意抑壓的話相當有機會會導致不良的副作用效果。985Please respect copyright.ＰＥＮＡＮＡQii2njtZ4p
985Please respect copyright.ＰＥＮＡＮＡqB3G5pZzDt
985Please respect copyright.ＰＥＮＡＮＡQlxJoDsNYt
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。985Please respect copyright.ＰＥＮＡＮＡgNQ9o1YTlS
985Please respect copyright.ＰＥＮＡＮＡkVDLHLfif3
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc985Please respect copyright.ＰＥＮＡＮＡLiIgYprNZi
985Please respect copyright.ＰＥＮＡＮＡBBwbLBsZOf
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。985Please respect copyright.ＰＥＮＡＮＡLzoiIpXML6
985Please respect copyright.ＰＥＮＡＮＡbOJmkyxa4S
Link:985Please respect copyright.ＰＥＮＡＮＡl8dGj9gzsC
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio985Please respect copyright.ＰＥＮＡＮＡsmvd7zNlxv
985Please respect copyright.ＰＥＮＡＮＡTRSduXqBqJ
985Please respect copyright.ＰＥＮＡＮＡz6kYkcVLqa
有興趣接收科普資訊的話，歡迎follow IG: potatopigtongue。985Please respect copyright.ＰＥＮＡＮＡNNKRf9GdzN
985Please respect copyright.ＰＥＮＡＮＡztxqUfo4Jd
985Please respect copyright.ＰＥＮＡＮＡACzDYB0ns9
Ref1:https://www.jci.org/articles/view/140223985Please respect copyright.ＰＥＮＡＮＡDy7EIgeivZ
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
