至今中國總共有三間生物公司的疫苗踏入Phase3狀態，包括為Cansino、Sinovac及Sinopharm。792Please respect copyright.ＰＥＮＡＮＡo4l00pG7AH
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其中Sinovac (Phase 3地點:巴西）及國營的Sinopharm(Ref2) (Phase 3地點:阿聯酋）兩間均用上滅活病毒疫苗(Inactivated Virus Vaccine)設計，本文將會就此作深入探討。792Please respect copyright.ＰＥＮＡＮＡbQTTOy31KR
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（圖1）滅活病毒疫苗，顧名思義就是將病毒除去感染能力，當作疫苗之用。792Please respect copyright.ＰＥＮＡＮＡwPmc4M1dwc
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下列為Sinovac製作滅活病毒疫苗的扼要流程(Ref3)792Please respect copyright.ＰＥＮＡＮＡnzkC56Hbbx
792Please respect copyright.ＰＥＮＡＮＡ6L2s2ryurN
1.從一名進入深切治療部的中國病患肺部體液中抽取病毒。792Please respect copyright.ＰＥＮＡＮＡenoZPz1xYs
792Please respect copyright.ＰＥＮＡＮＡxqjvGAj3Ds
2.經過數輪實驗室細胞的培植，使病毒數量增加。792Please respect copyright.ＰＥＮＡＮＡSUaeqbTpGg
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3.加入化學物消減病毒的感染力和多重過濾，取得弱化的武肺病毒。792Please respect copyright.ＰＥＮＡＮＡU5Ya6RZCo0
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4.將其製成可注射的疫苗。792Please respect copyright.ＰＥＮＡＮＡBDvOdHoTMn
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（圖2）將滅活病毒疫苗注射到身體後，身體的免疫細胞便會製作對應弱化病毒的抗體。792Please respect copyright.ＰＥＮＡＮＡdq6WZkiZkj
792Please respect copyright.ＰＥＮＡＮＡ8mVFOz5LVM
在繼續講述抗體之前，可先閱覽（圖3）溫故知新一下武肺入侵人體細胞的簡要過程，又或者可以到之前我所寫的文章觀看略為詳細的版本。792Please respect copyright.ＰＥＮＡＮＡw9STKPKeQg
https://www.penana.com/article/466568792Please respect copyright.ＰＥＮＡＮＡz7SDeafgv5
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（圖4）抗體（Antibody)頂多只能阻礙病毒進入細胞或者指示其他免疫細胞前來清滅病毒，並無獨立能力清滅病毒。792Please respect copyright.ＰＥＮＡＮＡfGYddDXW3l
792Please respect copyright.ＰＥＮＡＮＡ9D2U5n0CIH
而能夠阻礙病毒進入細胞的抗體，我們將稱之為Neutralizing Antibody，而圖中已列出其中的兩款機制。792Please respect copyright.ＰＥＮＡＮＡi1B2nWoWga
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1.抗體與病毒的S protein合併，792Please respect copyright.ＰＥＮＡＮＡApwNdwzljN
防止條件1的達成。792Please respect copyright.ＰＥＮＡＮＡbIl0edQVSz
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2.抗體與病毒其他位置合併，792Please respect copyright.ＰＥＮＡＮＡPNoYRVCRSB
防止條件3的達成。792Please respect copyright.ＰＥＮＡＮＡV8fHIeumgb
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（圖5）用上滅活病毒疫苗的話，抗體的製作便會針對病毒的各個位置而進行。792Please respect copyright.ＰＥＮＡＮＡmGmMud9VVh
基於並非所有抗體也能夠拼合在病毒的關鍵位置，不能夠阻礙病毒進入細胞的抗體，我們將稱之為Non-Neutralizing Antibody。792Please respect copyright.ＰＥＮＡＮＡ3UhVWHyc5m
792Please respect copyright.ＰＥＮＡＮＡBEG2GGgtZE
不過，就算是Non-Neutralizing Antibody，它亦能有能力標示病毒，指引其他免疫細胞前來清滅病毒。792Please respect copyright.ＰＥＮＡＮＡRNJWjcEqRJ
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（圖6）Non-Neutralizing Antibody的出現，將會引伸出一個名為Antibody Dependent Enhancement(ADE)的重要問題;792Please respect copyright.ＰＥＮＡＮＡtLlaIql6wG
簡單來說，就是抗體適得其反地協助病毒入侵人體細胞。792Please respect copyright.ＰＥＮＡＮＡWO2xfx3k8R
792Please respect copyright.ＰＥＮＡＮＡh97ExR5d9k
免疫細胞的表面上，有著接收器識辨抗體的某個區域。792Please respect copyright.ＰＥＮＡＮＡlu1lM0Nv39
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但若果有過多Non-Neutralizing Antibody黏在病毒裡頭的話，病毒就有機會可以無視之前那3條法則，不需要經過ACE2，而是透過免疫細胞的表面上識辨抗體的接收器進入細胞。792Please respect copyright.ＰＥＮＡＮＡqyZKObj9L0
792Please respect copyright.ＰＥＮＡＮＡoblTR9CmJX
換句話說，抗體在這情況下變相成為幫兇或者25仔，輔助病毒進入細胞，這現象我們稱之為ADE。792Please respect copyright.ＰＥＮＡＮＡY54DDOljhY
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（圖7）武肺病毒進入細胞後，需要切割S protein才能夠開始進行繁殖工作。792Please respect copyright.ＰＥＮＡＮＡd5RFVN5dKI
所以就算有Non-Neutralizing antibody做25仔，如果病毒幸運地有Neutralizing antibody保護S protein免受切割的話，病毒依舊無法作惡。792Please respect copyright.ＰＥＮＡＮＡXQ3ij8FJwp
792Please respect copyright.ＰＥＮＡＮＡkzk016TdqI
但若果無Neutralizing antibody保護的話，病毒就會利用免疫細胞作為寄主，避開一切免疫機制，大量製造病毒。792Please respect copyright.ＰＥＮＡＮＡ3ilqiJwwXT
情形就好像本身理應維護法紀的警察，突然之間搖身一變成為罪惡的溫床，窩藏及協助罪犯（病毒）滋生，導致情況一發不可收拾。792Please respect copyright.ＰＥＮＡＮＡacefIi8hVu
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（圖8）ADE這現象，科學家一直以來均有記錄及研究。（Ref4)792Please respect copyright.ＰＥＮＡＮＡKDYlt5czlt
以登革熱為例，病人染上登革熱病毒(Dengue Virus)的話，身體便會製造登革熱病毒抗體。792Please respect copyright.ＰＥＮＡＮＡIemgFMyVfh
但基於登革熱病毒與寨卡病毒(Zika Virus)有頗為相似的地方，某部份的登革熱病毒抗體「幸運地」便成為寨卡病毒的Non-Neutralizing Antibody，透過ADE幫忙寨卡病毒入侵人體。792Please respect copyright.ＰＥＮＡＮＡYZmzAaT5xd
792Please respect copyright.ＰＥＮＡＮＡY9C3SIjSTt
亦即是說，擁有登革熱病毒抗體的人反而更有機會受到寨卡病毒入侵。792Please respect copyright.ＰＥＮＡＮＡAZaQeOoW5Q
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（圖9）有研究指出，03年SARS病毒亦會依靠未曾上市的疫苗所產生出的Non-Neutralizing Antibody，不需經過ACE2便能入侵免疫細胞。（Ref5)792Please respect copyright.ＰＥＮＡＮＡdJYzOcjAi5
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武肺會否出現同樣現象，暫時尚未清楚。792Please respect copyright.ＰＥＮＡＮＡVoMZEqN7PB
792Please respect copyright.ＰＥＮＡＮＡmDlMRaH4p3
只不過各國進行Phase3中的疫苗，大多也是針對著武肺病毒S protein位置而設計，故此出現Non-Neutralizing antibody將會比用上整個武肺病毒而作為疫苗設計的那兩間公司為低，ADE的機率亦相對減少。792Please respect copyright.ＰＥＮＡＮＡ5sICyFSW1A
792Please respect copyright.ＰＥＮＡＮＡrqv7ksM113
當然，另一方面來看，中國那兩間公司因為用上整個武肺病毒來設計疫苗，理論上所產生的抗體數量及濃度亦會為高，抵抗的效果亦會相對顯著，但ADE的機率出現亦會相對為高。792Please respect copyright.ＰＥＮＡＮＡl2Env32uq1
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美國Moderna已表示Phase3的報告將會探討ADE的可能，但願中國Sinovac及國營Sinopharm的Phase3報告，也會在ADE方面進行深入探討吧！792Please respect copyright.ＰＥＮＡＮＡO5pawa9tLI
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。792Please respect copyright.ＰＥＮＡＮＡ12SZFnBzKF
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc792Please respect copyright.ＰＥＮＡＮＡupADadlY4g
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。792Please respect copyright.ＰＥＮＡＮＡ9QIKVSr6KA
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Link:792Please respect copyright.ＰＥＮＡＮＡQuJBzhRjxe
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio792Please respect copyright.ＰＥＮＡＮＡ24QnMjjSHM
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有興趣接收科普資訊的話，歡迎follow IG: potatopigtongue。792Please respect copyright.ＰＥＮＡＮＡ59A1Dquejc
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Ref2:https://jamanetwork.com/journals/jama/fullarticle/2769612?fbclid=IwAR0sp9eU5V9FOzuLjz6ERw6LRFm-1yx3MJt1OEgqBDQKW1GA5mQeIIi5J7E792Please respect copyright.ＰＥＮＡＮＡkodRzaJ7ll
Ref3:https://science.sciencemag.org/content/369/6499/77?fbclid=IwAR29zOO06gVsQAC2jLU2uMJi-qcYbniz108Y4kcaWOr1iNuQyVM3jCFMHa4792Please respect copyright.ＰＥＮＡＮＡtV4xZDD91U
Ref4:https://www.nature.com/articles/s41586-020-2538-8.pdf792Please respect copyright.ＰＥＮＡＮＡ6mF6RNVse1
Ref5:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115629/792Please respect copyright.ＰＥＮＡＮＡozj7JlvM43
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