減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1081Please respect copyright.ＰＥＮＡＮＡ9od8QZi8Gk
1081Please respect copyright.ＰＥＮＡＮＡxdoodkeiVf
1081Please respect copyright.ＰＥＮＡＮＡs71jyOhj8Z
一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1081Please respect copyright.ＰＥＮＡＮＡwmu37Wq015
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1081Please respect copyright.ＰＥＮＡＮＡOBjeCJ312w
1081Please respect copyright.ＰＥＮＡＮＡp4S1gEhOP8
1081Please respect copyright.ＰＥＮＡＮＡmgIe2Zzmtk
(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1081Please respect copyright.ＰＥＮＡＮＡ78kCT8tkmT
1081Please respect copyright.ＰＥＮＡＮＡ0uT8scTihk
1081Please respect copyright.ＰＥＮＡＮＡQnbNGdSWzU
以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1081Please respect copyright.ＰＥＮＡＮＡ9LosKxKJZE
1081Please respect copyright.ＰＥＮＡＮＡmyL8pkiobK
相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1081Please respect copyright.ＰＥＮＡＮＡI5YYabz5qM
1081Please respect copyright.ＰＥＮＡＮＡZmdsdr0eK8
老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1081Please respect copyright.ＰＥＮＡＮＡ7cnRJbgqK6
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1081Please respect copyright.ＰＥＮＡＮＡOZBHSSzL56
1081Please respect copyright.ＰＥＮＡＮＡVGWx1kmgKE
1081Please respect copyright.ＰＥＮＡＮＡoTHJrxkSLO
(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1081Please respect copyright.ＰＥＮＡＮＡ7W3hOWxsxy
1081Please respect copyright.ＰＥＮＡＮＡ69ptpaIEOg
1081Please respect copyright.ＰＥＮＡＮＡx0gfx8Tkii
第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1081Please respect copyright.ＰＥＮＡＮＡkuWSMO8lv7
1081Please respect copyright.ＰＥＮＡＮＡzfrgTR5kQB
而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1081Please respect copyright.ＰＥＮＡＮＡTgIZ1NUA9E
1081Please respect copyright.ＰＥＮＡＮＡfz0XBpgVnQ
1081Please respect copyright.ＰＥＮＡＮＡ3Dt2bzga3C
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1081Please respect copyright.ＰＥＮＡＮＡTd2bShzvwT
1081Please respect copyright.ＰＥＮＡＮＡum2EFNbsib
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1081Please respect copyright.ＰＥＮＡＮＡcDk1tj3VSx
1081Please respect copyright.ＰＥＮＡＮＡCtCqvf4NK5
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1081Please respect copyright.ＰＥＮＡＮＡXhQGuzfqEC
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Link:1081Please respect copyright.ＰＥＮＡＮＡPlk5mvhl6Z
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1081Please respect copyright.ＰＥＮＡＮＡm2mGRQ8rqT
1081Please respect copyright.ＰＥＮＡＮＡyL6Ye5h2mV
1081Please respect copyright.ＰＥＮＡＮＡfcRiYjEUVc
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1081Please respect copyright.ＰＥＮＡＮＡEpcNbVjqmT
1081Please respect copyright.ＰＥＮＡＮＡoeJBN1B0e7
Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1081Please respect copyright.ＰＥＮＡＮＡQKAh4a0XNz
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661081Please respect copyright.ＰＥＮＡＮＡz6zTH1sJjH
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1081Please respect copyright.ＰＥＮＡＮＡVLWCRDboMh
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1081Please respect copyright.ＰＥＮＡＮＡfwuYqceyWe
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1081Please respect copyright.ＰＥＮＡＮＡW3vy171ZEZ
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