癌細胞所在的環境裡，佈滿各式各樣的細胞。392Please respect copyright.ＰＥＮＡＮＡgeSS0TiDvg
392Please respect copyright.ＰＥＮＡＮＡumppk76YfA
392Please respect copyright.ＰＥＮＡＮＡzl27cwAG2D
當中有為數不少的是免疫細胞，只可是癌細胞發展出不同的機制躲避免疫細胞的攻勢，因此周遭的免疫細胞並沒能發揮其殺滅不良細胞的功效。392Please respect copyright.ＰＥＮＡＮＡwALBAQn3wa
392Please respect copyright.ＰＥＮＡＮＡ6SebyoXgDh
無論如何，它們同在一個環境裡，無可避免要面對一個問題，就是如何分配糧食。392Please respect copyright.ＰＥＮＡＮＡjDrUvVwt7T
392Please respect copyright.ＰＥＮＡＮＡ4wOMxt2OTO
(圖2)在癌細胞所在的環境裡，以葡萄糖(Glucose)及麩醯胺酸(Glutamine)為營養界別含量最多的兩大元首。392Please respect copyright.ＰＥＮＡＮＡ8V6tarqGGZ
392Please respect copyright.ＰＥＮＡＮＡyw0Rr0cfHq
392Please respect copyright.ＰＥＮＡＮＡsIkFxRcyku
研究發現，如果對比單一細胞的營養吸收速度的話，免疫細胞吸取葡萄糖的速度比癌細胞的為快。392Please respect copyright.ＰＥＮＡＮＡJ2MWT5yN82
392Please respect copyright.ＰＥＮＡＮＡzF9Y0yfA75
反之，癌細胞吸取麩醯胺酸的速度則比免疫細胞的為快。392Please respect copyright.ＰＥＮＡＮＡKYrEmrtHrA
392Please respect copyright.ＰＥＮＡＮＡaIOTv3UCBI
392Please respect copyright.ＰＥＮＡＮＡWQt6wekSuL
(圖3)重要的是，如果利用藥物阻截兩款細胞吸取麩醯胺酸的話，它們均會啟動機制加快吸收葡萄糖的速度，從而彌補營養所需。392Please respect copyright.ＰＥＮＡＮＡedwCfUFgdK
392Please respect copyright.ＰＥＮＡＮＡsqneHfU7sb
392Please respect copyright.ＰＥＮＡＮＡZ18h6sDu82
換句話說，它們配備使用及吸收兩種營養的能力，可根據環境供求而隨時變陣。392Please respect copyright.ＰＥＮＡＮＡWNSHUJemhy
392Please respect copyright.ＰＥＮＡＮＡqFMKOYdXeD
392Please respect copyright.ＰＥＮＡＮＡrQulfGaFL9
(圖4)雖然免疫細胞吸取葡萄糖的速度比癌細胞的為快，但如果計算整個環境的吸收總量的話，基於癌細胞數量多於免疫細胞，癌細胞共吸收環境葡萄糖總量達70%有多，而其餘免疫細胞的吸取量則只佔餘下的30%。392Please respect copyright.ＰＥＮＡＮＡzbA4l6mMkM
392Please respect copyright.ＰＥＮＡＮＡfRDPXZkfG2
392Please respect copyright.ＰＥＮＡＮＡnPJ2YDUdG6
亦即是說，依靠葡萄糖吸取量來探測癌細胞存在的技術(FDG-PET)，其癌細胞所在的環境至少有30%的訊號是來自免疫細胞，而非癌細胞。392Please respect copyright.ＰＥＮＡＮＡvdBCFfWaE3
392Please respect copyright.ＰＥＮＡＮＡGCwhcpS72Q
392Please respect copyright.ＰＥＮＡＮＡNtyJGkPuLE
392Please respect copyright.ＰＥＮＡＮＡCMrPIgQaYw
392Please respect copyright.ＰＥＮＡＮＡPymFcQkgCG
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。392Please respect copyright.ＰＥＮＡＮＡLiUk2gy3Rp
392Please respect copyright.ＰＥＮＡＮＡwAHc1ey10F
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc392Please respect copyright.ＰＥＮＡＮＡK6GuEJbivH
392Please respect copyright.ＰＥＮＡＮＡX7cNl95jCE
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。392Please respect copyright.ＰＥＮＡＮＡni6dIlIJJX
392Please respect copyright.ＰＥＮＡＮＡKZi3IzPJ4h
Link:392Please respect copyright.ＰＥＮＡＮＡ11C4bahTIU
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio392Please respect copyright.ＰＥＮＡＮＡovaOUpygpk
392Please respect copyright.ＰＥＮＡＮＡMDmevNgv7t
392Please respect copyright.ＰＥＮＡＮＡzlOKIEUJER
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。392Please respect copyright.ＰＥＮＡＮＡDO76QxVEBp
392Please respect copyright.ＰＥＮＡＮＡmAVE5tN0UL
Ref1https://www.nature.com/articles/s41586-021-03442-1#MOESM3392Please respect copyright.ＰＥＮＡＮＡkPNkcfFUH1
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
