上兩集簡述了癌細胞缺氧的成因，以及缺氧導致癌細胞相對上更為依賴葡萄糖作新陳代謝用途。630Please respect copyright.ＰＥＮＡＮＡfRMmg1SRwt
630Please respect copyright.ＰＥＮＡＮＡAYpVMNFSNz
630Please respect copyright.ＰＥＮＡＮＡinEOuBc0ms
三十秒科學–腫瘤的周遭環境630Please respect copyright.ＰＥＮＡＮＡlqqwC7z2SO
https://lih.kg/gFPfPS630Please respect copyright.ＰＥＮＡＮＡAfZXGuoWUT
630Please respect copyright.ＰＥＮＡＮＡOI3CPYLbLh
三十秒科學–癌細胞嗜糖的原因630Please respect copyright.ＰＥＮＡＮＡRHA36xVmuW
https://lih.kg/2416199630Please respect copyright.ＰＥＮＡＮＡwnuOwRQdKU
630Please respect copyright.ＰＥＮＡＮＡ6hwaRbZMU9
今集我們會講述缺氧對癌細胞自身發展的其中一道好處。630Please respect copyright.ＰＥＮＡＮＡi8tqovVJit
630Please respect copyright.ＰＥＮＡＮＡP33NavXpeN
（圖2）當DNA出現異變的時候，細胞裡名為p53的蛋白質便會出手幫忙，號令細胞停止生長(Cell cycle arrest)，給予時間讓其他蛋白質幫忙協助修復DNA。630Please respect copyright.ＰＥＮＡＮＡ9aqa2k3bLk
630Please respect copyright.ＰＥＮＡＮＡc9ZylEPJeB
630Please respect copyright.ＰＥＮＡＮＡ3SLJEa8SMh
若果細胞最後還是無法處理修復DNA的工作，p53便會指示細胞趨向死亡程序(Apoptosis)。630Please respect copyright.ＰＥＮＡＮＡgrqblCQ1CC
630Please respect copyright.ＰＥＮＡＮＡAvlhOB7qZ2
腫瘤的出現，是無數DNA變異得出來的成果。因此在這方面來看，p53是防止癌細胞出現的好幫手，因為p53會確保細胞的DNA不會出現變異，或指令出現DNA變異的細胞消失。630Please respect copyright.ＰＥＮＡＮＡYABPdnOwSP
630Please respect copyright.ＰＥＮＡＮＡAnDAGmxvZw
但是，有一點非常矛盾的是，大部份普通細胞的p53蛋白質表達率非常低，它能否防止癌細胞出現這一點使人存疑。630Please respect copyright.ＰＥＮＡＮＡWPLfVvmdOb
630Please respect copyright.ＰＥＮＡＮＡuNcVXCd8eT
（圖3）事實上，非常諷刺的是，氧氣含量越低的話，P53蛋白質的表達率便會越高。630Please respect copyright.ＰＥＮＡＮＡJjNEC0lcBM
630Please respect copyright.ＰＥＮＡＮＡMz1YzBoAbf
630Please respect copyright.ＰＥＮＡＮＡBbIZ59vIjG
而在缺氧的環境下，擁有p53的蛋白質的細胞便會自動進行死亡。630Please respect copyright.ＰＥＮＡＮＡKRTW9QF3Ox
630Please respect copyright.ＰＥＮＡＮＡzG8MbBLUUD
（圖4）重大的問題是，有部份缺氧的癌細胞會發展出變異版本的p53，失去原有的功能。630Please respect copyright.ＰＥＮＡＮＡZTfJMiBvgZ
在缺氧施加的壓力下，擁有正常p53版本的細胞會一一死去，變相幫忙篩選出擁有變異版本p53的細胞，使它們逐漸成為大多數。630Please respect copyright.ＰＥＮＡＮＡR6LzCLkToe
630Please respect copyright.ＰＥＮＡＮＡ7Zf1XxbSGQ
630Please respect copyright.ＰＥＮＡＮＡ9DsdOTjfNz
而這些擁有變異版本p53的細胞，修復DNA的能力會大幅度被削弱，因而加劇了DNA變異速度，促成腫瘤繼續長大。630Please respect copyright.ＰＥＮＡＮＡr7ehLE9wKo
630Please respect copyright.ＰＥＮＡＮＡy4DYEFapNE
（圖5）圖中為腫瘤形成的其中一道概論，癌細胞自製的缺氧環境，變相提供了一道挑選擁有更強DNA變異能力細胞的環境。630Please respect copyright.ＰＥＮＡＮＡZC9WCyHpwI
630Please respect copyright.ＰＥＮＡＮＡ4Hu0IZEdVC
630Please respect copyright.ＰＥＮＡＮＡLag6rRUjmL
現實中大部分的的癌細胞均擁有p53變異，而擁有p53變異的細胞更具抵抗化療藥物cis-platin的能力。630Please respect copyright.ＰＥＮＡＮＡ2s73lRuAja
630Please respect copyright.ＰＥＮＡＮＡTBfqVKbnRj
除缺氧外，大陽的紫外光亦是促使p53變異的好幫手，不少皮膚癌細胞均出現至少一處的p53變異。630Please respect copyright.ＰＥＮＡＮＡkZGarYu9By
630Please respect copyright.ＰＥＮＡＮＡQNsNXblAiz
那些不塗防曬便與陽光玩遊戲的人，一直是在玩命。630Please respect copyright.ＰＥＮＡＮＡucKiAzhtZd
630Please respect copyright.ＰＥＮＡＮＡyIDQ4hxTdG
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。630Please respect copyright.ＰＥＮＡＮＡGOHuK1hXYk
630Please respect copyright.ＰＥＮＡＮＡyjBPmqAKhA
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc630Please respect copyright.ＰＥＮＡＮＡDkKt0eMOLD
630Please respect copyright.ＰＥＮＡＮＡnu1KUIIsir
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。630Please respect copyright.ＰＥＮＡＮＡ7RWuFkGcCs
630Please respect copyright.ＰＥＮＡＮＡvLNXYStaj8
Link:630Please respect copyright.ＰＥＮＡＮＡhMRKBjp4dV
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio630Please respect copyright.ＰＥＮＡＮＡ0Zl2h1JifO
630Please respect copyright.ＰＥＮＡＮＡDFTajSbDfz
630Please respect copyright.ＰＥＮＡＮＡ66PV5svV4C
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。630Please respect copyright.ＰＥＮＡＮＡLXIFZ1Qk10
630Please respect copyright.ＰＥＮＡＮＡr299BAsusn
Ref1:https://pubmed.ncbi.nlm.nih.gov/8538748/630Please respect copyright.ＰＥＮＡＮＡLQkjR75cHE
