世界非常殘酷，美味可口的食物很多時候都是高脂高卡路里。907Please respect copyright.ＰＥＮＡＮＡDsXLo66Bks
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如果餐單的卡路里長期是以脂肪為主導的話，又是否會更容易產生癌症呢?907Please respect copyright.ＰＥＮＡＮＡ1EPcOnw4mu
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（圖2）有科學家對此進行研究（Ref1)，餵食老鼠為期7日脂肪佔總卡路里約60%的餐單，然後再透過血管移植人類的口腔癌細胞，其後密切跟進腫瘤的狀況。907Please respect copyright.ＰＥＮＡＮＡm7YM9tnbGI
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如何跟進? 就是用上集所介紹的螢光技術。907Please respect copyright.ＰＥＮＡＮＡP1x1zrtFFz
907Please respect copyright.ＰＥＮＡＮＡeDUeYth0Hg
詳情可見：三十秒科學–透視癌細胞907Please respect copyright.ＰＥＮＡＮＡQE26VryAqa
- 分享自 LIHKG 討論區907Please respect copyright.ＰＥＮＡＮＡ3V3IrITcA0
https://lih.kg/2408323907Please respect copyright.ＰＥＮＡＮＡI13RK36BCc
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（圖3）從圖中可以看得見，進食脂肪主導餐單的老鼠，原生腫瘤的體積不但更為巨大，而且亦有更高機率出現癌細胞轉移的情況。907Please respect copyright.ＰＥＮＡＮＡP9sz6o9WAg
907Please respect copyright.ＰＥＮＡＮＡDeOUapkcSZ
907Please respect copyright.ＰＥＮＡＮＡY9lK0xyCuQ
CD36是輔助細胞吸取脂肪酸的蛋白質，當癌細胞的CD36被除去的時候，莫論餐單是否由脂肪主導，原生腫瘤的體積均沒有顯著大變化，而且亦沒有出現癌細胞轉移的情況。907Please respect copyright.ＰＥＮＡＮＡdVvX9354od
907Please respect copyright.ＰＥＮＡＮＡxMroNIPMUX
（圖4）當細胞遇上棕櫚酸約兩日後，細胞的CD36蛋白質數量亦會因而上升 。907Please respect copyright.ＰＥＮＡＮＡIPgOjnfN6c
907Please respect copyright.ＰＥＮＡＮＡKOWOxGmPE8
907Please respect copyright.ＰＥＮＡＮＡWNmzVlxcNj
從右圖中可以清晰見得到，經過棕櫚酸「調教」過的癌細胞，移植到老鼠後會出現非常明顯的癌細胞轉移過程。907Please respect copyright.ＰＥＮＡＮＡgM7af9KJDI
而當癌細胞的CD36蛋白質被移除後，癌細胞轉移過程亦再沒有發生。907Please respect copyright.ＰＥＮＡＮＡIJxqNx8IgQ
907Please respect copyright.ＰＥＮＡＮＡfK5bFWW9Dp
現時有不少藥物嘗試針對CD36來醫治癌細胞或阻止其進行轉移的程序，但不少藥物均在第二期臨床研究裡頭因為出現副作用或效率未如預期被迫中斷。907Please respect copyright.ＰＥＮＡＮＡn9aRBYsVB8
907Please respect copyright.ＰＥＮＡＮＡe9LdMxTU83
或許需要更多研究理解CD36在細胞的作用或機制，才能設計出輕微副作用的治癌藥物。907Please respect copyright.ＰＥＮＡＮＡgWtQgGb1cG
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。907Please respect copyright.ＰＥＮＡＮＡ3D6rI6Ho1e
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc907Please respect copyright.ＰＥＮＡＮＡLAGkHPKsMn
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。907Please respect copyright.ＰＥＮＡＮＡWqKRTg0EaB
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Link:907Please respect copyright.ＰＥＮＡＮＡ2qsgoafHRH
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio907Please respect copyright.ＰＥＮＡＮＡmAISa8RckG
907Please respect copyright.ＰＥＮＡＮＡKgCtj08Yz1
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。907Please respect copyright.ＰＥＮＡＮＡCedtiffyBE
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Ref1:https://pubmed.ncbi.nlm.nih.gov/27974793/907Please respect copyright.ＰＥＮＡＮＡCXfWY00GU1
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