不少的癌症病人均會出現體重及BMI急速下降的情況,肌肉會出現萎縮,脂肪組織亦有機會有所消耗,這現象稱之為Cancer-associated cachexia(CAC)。486Please respect copyright.PENANAfnLKXqHwFR486Please respect copyright.PENANAe0cd8nULyc
486Please respect copyright.PENANA6fW8peQmGz
與厭食症不同的是,體重的流失並沒能依靠增加進食來進行完全填補。486Please respect copyright.PENANASLOk2BrXXM
486Please respect copyright.PENANAa7P68hTzTN
(圖2)CAC的形成,是腫瘤與身體多種器官互動後所得出的結果,箇中涉及新陳代謝及荷爾蒙的轉變。486Please respect copyright.PENANAIgozEmNZbb486Please respect copyright.PENANAFoZPuvRQsw
486Please respect copyright.PENANAtG4VL3uJFS
486Please respect copyright.PENANAAQHOnkNLRO
(圖3)從圖中所見,老鼠出現腫瘤約21日後,腿部肌肉出現萎縮,與人類的CAC現象吻合。486Please respect copyright.PENANAKDg0ZTJc3N486Please respect copyright.PENANAzk751e9vcX
486Please respect copyright.PENANAa1j4AyCDqb
PTHrP是一種某類型的腫瘤釋放到血管的蛋白質,而往老鼠注射PTHrP蛋白質抗體的話,肌肉的萎縮程度亦有所緩和。486Please respect copyright.PENANAqEUhGsEhxi
486Please respect copyright.PENANAAsrjI2j3Io
只可是,往健康老鼠注射PTHrP蛋白質的話,肌肉並不會貿然萎縮,而往出現腫瘤的老鼠注射PTHrP蛋白質的話,肌肉萎縮的程度反會更加劇烈。486Please respect copyright.PENANA6V6nEnpxuc
486Please respect copyright.PENANAR7GHGVivM0
這亦證明,PTHrP蛋白質只是導致癌症時候肌肉萎縮的其中一道組件,還需要癌細胞另外的付出才可達成。486Please respect copyright.PENANATtTDQrt9R3
486Please respect copyright.PENANAbHJTj1tZS3
486Please respect copyright.PENANA864PwY0M4G
癌症所帶來的CAC現象,會導致藥物對其他正常器官出現更強烈的副作用及毒性。這變相需要降低用藥的劑量作出配合,因而減低了滅癌的效率。486Please respect copyright.PENANAneKW0LuOYt
486Please respect copyright.PENANAhIDTOWkFuJ
因此,現今科學家亦在努力嘗試找出CAC的整套機制,務求找出有效的醫學方法制止CAC的產生。486Please respect copyright.PENANAVeH0zLJgeq
486Please respect copyright.PENANAhM7hjZ7tAY
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。486Please respect copyright.PENANAg6b5aR29Fd
486Please respect copyright.PENANAThPyYgTSx4
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc486Please respect copyright.PENANAIHDyIBelEG
486Please respect copyright.PENANAriBT4m0Ysv
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。486Please respect copyright.PENANAm4Suj3LlJt
486Please respect copyright.PENANAGpQ9Jt9xkC
Link:486Please respect copyright.PENANAsAdX58AeuZ
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio486Please respect copyright.PENANAHNonRFE2H7
486Please respect copyright.PENANADmkd02JE6e
486Please respect copyright.PENANAUTu6dRLNeY
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。486Please respect copyright.PENANAkZXmbZG1jL
486Please respect copyright.PENANAtFLoL2Rqj4
Ref1:https://www.nature.com/articles/nature13528486Please respect copyright.PENANAAUURckVjZt