不少的癌症病人均會出現體重及BMI急速下降的情況,肌肉會出現萎縮,脂肪組織亦有機會有所消耗,這現象稱之為Cancer-associated cachexia(CAC)。490Please respect copyright.PENANAegM6Wt7mWG490Please respect copyright.PENANAEHpp53NGSB
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與厭食症不同的是,體重的流失並沒能依靠增加進食來進行完全填補。490Please respect copyright.PENANAv8Akkf8IdN
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(圖2)CAC的形成,是腫瘤與身體多種器官互動後所得出的結果,箇中涉及新陳代謝及荷爾蒙的轉變。490Please respect copyright.PENANAPlfbu6QYSE490Please respect copyright.PENANAh7qaXIPcph
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(圖3)從圖中所見,老鼠出現腫瘤約21日後,腿部肌肉出現萎縮,與人類的CAC現象吻合。490Please respect copyright.PENANASvdZNFTBwd490Please respect copyright.PENANABxAnmahVLw
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PTHrP是一種某類型的腫瘤釋放到血管的蛋白質,而往老鼠注射PTHrP蛋白質抗體的話,肌肉的萎縮程度亦有所緩和。490Please respect copyright.PENANAbo37PVMvPw
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只可是,往健康老鼠注射PTHrP蛋白質的話,肌肉並不會貿然萎縮,而往出現腫瘤的老鼠注射PTHrP蛋白質的話,肌肉萎縮的程度反會更加劇烈。490Please respect copyright.PENANAj1sKBCoXpE
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這亦證明,PTHrP蛋白質只是導致癌症時候肌肉萎縮的其中一道組件,還需要癌細胞另外的付出才可達成。490Please respect copyright.PENANA9P7Kyl7akJ
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癌症所帶來的CAC現象,會導致藥物對其他正常器官出現更強烈的副作用及毒性。這變相需要降低用藥的劑量作出配合,因而減低了滅癌的效率。490Please respect copyright.PENANA9tTDjdSl9A
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因此,現今科學家亦在努力嘗試找出CAC的整套機制,務求找出有效的醫學方法制止CAC的產生。490Please respect copyright.PENANAbD1nYs7mXu
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。490Please respect copyright.PENANAWV2iuQtSpb
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Ref1:https://www.nature.com/articles/nature13528490Please respect copyright.PENANAl7KPFyOIzw