肌肉大概佔據身體重量的40%。436Please respect copyright.PENANAAv32JOozKp436Please respect copyright.PENANAUGOTshcKCg
436Please respect copyright.PENANAPxzALbrypQ
踏入50歲後,平均每10年就會有15-30%的肌肉流失。436Please respect copyright.PENANAazjNclf5aN
436Please respect copyright.PENANArAIUoUTpP2
(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。436Please respect copyright.PENANAex0SHexv3H436Please respect copyright.PENANACmeySF5ajm
436Please respect copyright.PENANAW1GefsTkua
而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。436Please respect copyright.PENANAhIOBCOxxit
436Please respect copyright.PENANAClm9Ijd7F9
(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。436Please respect copyright.PENANAdQAVESCR3m
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。436Please respect copyright.PENANAVVcwnJnkrX436Please respect copyright.PENANA0dtb5O6g5e
436Please respect copyright.PENANAmWh0aG2bwj
當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。436Please respect copyright.PENANAYXGNjSAS0U
436Please respect copyright.PENANACr4Ieua9kw
相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。436Please respect copyright.PENANAKlfLY4H8fv
436Please respect copyright.PENANAwqwMFTXIzY
這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。436Please respect copyright.PENANAvErjCdbtV7
436Please respect copyright.PENANA5TJ0ke9luN
現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。436Please respect copyright.PENANAw2DaaD53A7
436Please respect copyright.PENANAw6vZWDRtYw
只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。436Please respect copyright.PENANA3h4faccTJM
436Please respect copyright.PENANASUSXFq4DGb
436Please respect copyright.PENANARRYeuMiVKR
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。436Please respect copyright.PENANAILcUG9x8GT
436Please respect copyright.PENANAnjJSBYmUhU
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc436Please respect copyright.PENANAqJ8MwJwLuU
436Please respect copyright.PENANA34p3ulSrh5
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。436Please respect copyright.PENANAYDxijHf8hj
436Please respect copyright.PENANASLHSKzdh4l
Link:436Please respect copyright.PENANAUvc6jDoDWg
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio436Please respect copyright.PENANARFoSSaSJmm
436Please respect copyright.PENANAnyS9ykEW8Q
436Please respect copyright.PENANAyeopYA0xWY
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。436Please respect copyright.PENANASqv5Tnw1w7
436Please respect copyright.PENANALq1Gh7lqqe
Ref1:https://science.sciencemag.org/content/371/6528/eabc8059436Please respect copyright.PENANA2crKis5pRl