化療殺滅癌細胞的效率非常參差,有些情況更反而會導致癌細胞加速生長,究竟為何會這樣?519Please respect copyright.PENANAuTTHUYYHij519Please respect copyright.PENANAZAyVz8qoyd
519Please respect copyright.PENANAyG20JbkQ3w
(圖2)使用化療藥物過後,某些癌細胞的確是會歸西死亡。519Please respect copyright.PENANAxGTameyfEr
而細胞死亡的方式有好幾種,其中兩種為Apoptosis及Necrosis。519Please respect copyright.PENANAWqZyclmaXe519Please respect copyright.PENANA9zXPCk63wG
519Please respect copyright.PENANAY5UBER0VRZ
如圖中所見,進行Apoptosis的細胞會呈完整球狀,屍體相對的體積較大。519Please respect copyright.PENANAFasaD81rt9
而進行Necrosis的細胞則會分成為不規則的碎塊,體積亦較細。519Please respect copyright.PENANACnb1WON9Pa
519Please respect copyright.PENANAy1jvBj5FSw
(圖3)形象化來說,Apoptosis就是曲奇餅,而Necrosis就是曲奇餅碎。519Please respect copyright.PENANAatDjYqZ0jF519Please respect copyright.PENANAeo5PdC9TkW
519Please respect copyright.PENANAhMD60h5P0O
519Please respect copyright.PENANA39V5w98I55
(圖4)癌細胞被化療藥物殺死後,若進行Necrosis,鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制,將死亡的細胞吞噬,作營養供用使自己繼續成長,抵禦化療藥物所帶來的困境。519Please respect copyright.PENANACHgxCHd8mW519Please respect copyright.PENANA6bw0Fcsy8M
519Please respect copyright.PENANAPSL172itrI
但細胞進行Apoptosis的話,因屍體體積過大,鄰近的細胞便不能把其吞噬。519Please respect copyright.PENANAVVvGPdHcew
519Please respect copyright.PENANA1GqycFTOTz
並不是所有癌細胞亦能懂得施展Macropinocytosis,而整個機制學界亦在模索之中,只知道某些基因如PI3K或Ras進行突變的話,Macropinocytosis發生的機率亦會較大。519Please respect copyright.PENANAbKZfg2iVoP
519Please respect copyright.PENANAqtRPJkjaX0
若能掌握整套機制及研發藥物制止Macropinocytosis的發生,並在化療藥物其間同時使用,便能壓抑癌細胞吞噬死亡細胞的機制,大大增加化療的效果。519Please respect copyright.PENANA5foVVdYSvT
519Please respect copyright.PENANAOkUyp4oro2
519Please respect copyright.PENANAqH8jmm3pTf
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。519Please respect copyright.PENANArX9QLZlkRU
519Please respect copyright.PENANAvdnprNc7c2
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc519Please respect copyright.PENANA224ocYfWLZ
519Please respect copyright.PENANAdFWh2TqFZz
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。519Please respect copyright.PENANAVhqiFFxrcs
519Please respect copyright.PENANAG1gWJEVZP8
Link:519Please respect copyright.PENANAjvJ9EjyxHr
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio519Please respect copyright.PENANAiK704qIsSb
519Please respect copyright.PENANAkGH7DARu0y
519Please respect copyright.PENANAaMk1RgKQLr
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。519Please respect copyright.PENANA4IUzT4I6Rd
519Please respect copyright.PENANAelbxwSxK68
Ref1:https://www.nature.com/articles/s41467-020-14928-3519Please respect copyright.PENANAYZMG7BNoxu