皮膚受傷的時候，大多數的情況下都會出現結焦情況，過一段時間後傷口便會縫合。966Please respect copyright.ＰＥＮＡＮＡkniqmIF78K
966Please respect copyright.ＰＥＮＡＮＡFXcasVkFP9
966Please respect copyright.ＰＥＮＡＮＡl5O3a0CKGI
有時候，皮膚會留有疤痕，但又有一些情況下會不留痕跡般似的進行修復，就像沒有事發生過一樣。966Please respect copyright.ＰＥＮＡＮＡbmD9lF4gFi
966Please respect copyright.ＰＥＮＡＮＡHZ4AdJ2m37
究竟最終會否留有疤痕，是看幸運還是甚麼呢？966Please respect copyright.ＰＥＮＡＮＡT0eRi0ESL8
966Please respect copyright.ＰＥＮＡＮＡyYVH2dpHVi
966Please respect copyright.ＰＥＮＡＮＡmeKTLG8IJP
（圖2）近日，有科學家發表文章(Ref1)，對此作出了一個頗為完滿的解答。966Please respect copyright.ＰＥＮＡＮＡibW1kyN00n
966Please respect copyright.ＰＥＮＡＮＡAD2giwAQDI
966Please respect copyright.ＰＥＮＡＮＡXdYGns7X4f
他們在老鼠耳仔上開一個細洞，然後再緊密觀察其康復情況。他們發現塗上會引起發炎作用的Imiquimod(IMQ)後，傷口會完美修復不留疤。966Please respect copyright.ＰＥＮＡＮＡzGHhCJcIfI
966Please respect copyright.ＰＥＮＡＮＡkKI8aKqEpA
而在缺乏TRPA1神經細胞的老鼠，就算塗上(IMQ)，傷口始終會留有疤痕，表示TRPA1神經細胞在皮膚的修復上顯然有著重要作用。966Please respect copyright.ＰＥＮＡＮＡhxZTr8Axy6
966Please respect copyright.ＰＥＮＡＮＡ9vLUNK0qAB
（圖3）他們進行了一系列的實驗，最終找出了箇中機制，以下為最簡化版本。966Please respect copyright.ＰＥＮＡＮＡ7TwTWJdBr8
966Please respect copyright.ＰＥＮＡＮＡS8uZLcJ268
966Please respect copyright.ＰＥＮＡＮＡyYrT747gNM
1.傷口塗上IMQ後，將會引起發炎作用。966Please respect copyright.ＰＥＮＡＮＡzjMGL3z2OB
2.發炎作用刺激TRPA1神經細胞。966Please respect copyright.ＰＥＮＡＮＡGAF0RwlCIp
3.免疫系統細胞（dermal dendritic cells、γδ T cells）被傳召前來。966Please respect copyright.ＰＥＮＡＮＡfVX6QU0bls
4.免疫系統細胞釋出相關物質（Interlunkin17、22、23）。966Please respect copyright.ＰＥＮＡＮＡIa3cQK6lmC
5.一系列的過程發生過後，肌膚完美修復。966Please respect copyright.ＰＥＮＡＮＡgjbDOmkZcy
966Please respect copyright.ＰＥＮＡＮＡmeryv7IoEB
966Please respect copyright.ＰＥＮＡＮＡQNPj3XhgfF
此研究的結果針對於老鼠的皮膚癒合情況，未必能套用在人類身上，需要作出人體試驗才能廣泛證實此結果。966Please respect copyright.ＰＥＮＡＮＡ4r7srlM5CC
另外，IMQ的塗用時機還需要進一步確認，何時觸發發炎作用才是適當的時機還需要一系列的測試。966Please respect copyright.ＰＥＮＡＮＡzGpVVaS5QN
966Please respect copyright.ＰＥＮＡＮＡ0YXcP1VKm0
不過有一點非常重要的是，當人類皮膚受傷的時候，自身是不會主動觸動TRPA1神經細胞。966Please respect copyright.ＰＥＮＡＮＡ8Zd2ezggqV
若然整個結果能套用在人類身上的話，那亦是代表我們日後可塗上適當的藥膏刺激皮膚下的TRPA1細胞，觸發一系列的過程使傷口以不留疤痕的方式完美癒合！966Please respect copyright.ＰＥＮＡＮＡZzeoVD9M8o
966Please respect copyright.ＰＥＮＡＮＡaTDmlAD2fD
966Please respect copyright.ＰＥＮＡＮＡHfunYkyS7v
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。966Please respect copyright.ＰＥＮＡＮＡBj3oEdemhH
966Please respect copyright.ＰＥＮＡＮＡF9s0txxEik
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc966Please respect copyright.ＰＥＮＡＮＡjG7nqa9t0e
966Please respect copyright.ＰＥＮＡＮＡvNKmslk2m2
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。966Please respect copyright.ＰＥＮＡＮＡQ85J7X7BAD
966Please respect copyright.ＰＥＮＡＮＡC7E3op0FU4
Link:966Please respect copyright.ＰＥＮＡＮＡrumOdmAhPY
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio966Please respect copyright.ＰＥＮＡＮＡ7HOzaatyyi
966Please respect copyright.ＰＥＮＡＮＡP4qbVIbvfz
最後亦請幫一幫忙簽署袁爸的白宮呈請，幫忙為香港出一份力。966Please respect copyright.ＰＥＮＡＮＡyN1R34RYCl
https://petitions.whitehouse.gov/petition/support-hong-kong-restart-clean-2020-legislative-council-election-now966Please respect copyright.ＰＥＮＡＮＡAHtyfWEz2X
966Please respect copyright.ＰＥＮＡＮＡHh622V7TUM
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。966Please respect copyright.ＰＥＮＡＮＡyWTw9yzmIy
966Please respect copyright.ＰＥＮＡＮＡhYG5KFuZ80
Ref1:https://immunology.sciencemag.org/content/5/50/eaba5683
00
ns3.144.250.2da2
