往不同動物例如老鼠及線蟲注射治療糖尿病的藥物(Metformin)後，壽命均會有顯著的增長。668Please respect copyright.ＰＥＮＡＮＡLwapBnq57a
668Please respect copyright.ＰＥＮＡＮＡAfIcaNtzHB
668Please respect copyright.ＰＥＮＡＮＡXzHkhZ8caY
有研究利用現成資料庫作對比，發現服用Metformin的糖尿病人歲數比沒有服用Metformin的健康人士為長(Ref1)，亦有臨床研究嘗試為14名70歲的健康老人家注射為期6星期的Metformin，藉觀察體內的轉變以作抗衰老藥的研究基礎(Ref2)。668Please respect copyright.ＰＥＮＡＮＡTlwkx8l0Nh
668Please respect copyright.ＰＥＮＡＮＡ274MvYhEym
（圖2）從圖中可見，往年輕線蟲注射Metformin的話，牠們的生存日子便會增長。668Please respect copyright.ＰＥＮＡＮＡbuV3qiWAve
668Please respect copyright.ＰＥＮＡＮＡNeqQvj3LOm
668Please respect copyright.ＰＥＮＡＮＡzhcEk3R5in
（圖3）但是，與年輕線蟲相反，往年老的線蟲注射Metformin的話，牠們的生存日子不但沒有增加，反而會減少。668Please respect copyright.ＰＥＮＡＮＡxDTbzhSUSM
668Please respect copyright.ＰＥＮＡＮＡgkwD3NnM7F
668Please respect copyright.ＰＥＮＡＮＡVPGbjrZFJN
668Please respect copyright.ＰＥＮＡＮＡq6RCqAUxPE
（圖4）經過一系列的實驗，科學家認為Metformin能夠驅使年輕線蟲延壽的其中一個原因，是與粒線體的整體功用有關(Ref3)。668Please respect copyright.ＰＥＮＡＮＡFvsUwPhvnh
668Please respect copyright.ＰＥＮＡＮＡI75YC2loPI
668Please respect copyright.ＰＥＮＡＮＡyDsX61xQee
其中，Metformin為年輕線蟲的新陳代謝作出轉變，包括增加碳水化合物的分解，減低脂肪的含量等，但年老的線蟲卻沒能夠觸發同樣的效果，反而更會因新陳代謝機制的不良負荷而增加死亡率。668Please respect copyright.ＰＥＮＡＮＡ6IUWTHrFFY
668Please respect copyright.ＰＥＮＡＮＡISXvtbbWWS
文中的科學家亦就此作出質疑，既然Metformin只能使年輕線蟲而非年老線蟲延壽，那又究竟是否值得「魯莽」地對健康老人家進行Metformin的延壽研究。668Please respect copyright.ＰＥＮＡＮＡHbkKKeqPbZ
668Please respect copyright.ＰＥＮＡＮＡIpkrEq6Yvc
668Please respect copyright.ＰＥＮＡＮＡ5DbqcqowEj
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。668Please respect copyright.ＰＥＮＡＮＡthDUkGSUIK
668Please respect copyright.ＰＥＮＡＮＡpnhCR3IKAS
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc668Please respect copyright.ＰＥＮＡＮＡ0eRZekvRpl
668Please respect copyright.ＰＥＮＡＮＡXoAMNgb8dY
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。668Please respect copyright.ＰＥＮＡＮＡzBPx6lBQTx
668Please respect copyright.ＰＥＮＡＮＡW4b4ABMWQR
Link:668Please respect copyright.ＰＥＮＡＮＡ1h64TQoXle
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio668Please respect copyright.ＰＥＮＡＮＡYBLS5ExHwh
668Please respect copyright.ＰＥＮＡＮＡmdNAhzXfhF
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。668Please respect copyright.ＰＥＮＡＮＡAW6rwGt2dl
668Please respect copyright.ＰＥＮＡＮＡCFDUCAgGQO
https://www.instagram.com/potatopigtongue/668Please respect copyright.ＰＥＮＡＮＡwll2JcsOZc
668Please respect copyright.ＰＥＮＡＮＡEalnptbPBo
668Please respect copyright.ＰＥＮＡＮＡ49pKFOTEd2
668Please respect copyright.ＰＥＮＡＮＡPiQrMCNcoX
668Please respect copyright.ＰＥＮＡＮＡLmZ1ioTbm7
Ref1:https://pubmed.ncbi.nlm.nih.gov/25041462/668Please respect copyright.ＰＥＮＡＮＡuZGgAR1OSG
Ref2:https://pubmed.ncbi.nlm.nih.gov/29383869/668Please respect copyright.ＰＥＮＡＮＡ7dryy5AS0k
Ref3:https://www.nature.com/articles/s42255-020-00307-1668Please respect copyright.ＰＥＮＡＮＡE8c1ixPtAn
Penana
search
登入arrow_drop_down
註冊arrow_drop_down
