當細胞裡頭出現多餘或者已受損毀的物質,又或者是細胞面臨營養不足的情況,細胞便會啟動名為自噬(Autophagy)的機制,依靠溶酶體(lysosome)將物質消化成為蛋白質/糖份/脂肪,供自己能量或物質所需。354Please respect copyright.PENANAx6AMoLFDnS
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早前亦有提及Cancer-associated fibroblasts如何利用自噬(Autophagy)幫助癌細胞生長。354Please respect copyright.PENANA4V1Krstfp0
三十秒科學–癌細胞也會自肥?354Please respect copyright.PENANAPuPMoAdHTo
- 分享自 LIHKG 討論區354Please respect copyright.PENANAwN6GObWvvk
https://lih.kg/hgfcNS354Please respect copyright.PENANAmDysMMQN5k
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(圖2)自噬(Autophagy)機制能夠讓細胞在營養不足的情況摧毀多餘的物質,使自己得以在困局下苟延殘喘。354Please respect copyright.PENANAA0gV1RDh5y
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情形就如人們債務纏身而又沒有收入抵債的時候,只好變賣自己所持有的資產,化成現金抵償。354Please respect copyright.PENANA2NUHVnzM6i
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由此可以想像,這是一道治標不治標的方法。354Please respect copyright.PENANA6xdlhDIL2h
當長期沒有營養流入細胞,而細胞再也沒有多餘物質進行自噬的時候,細胞便會啟動自行滅亡的機制。354Please respect copyright.PENANA4rtVnkkCgi
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(圖3)如果催谷癌細胞不斷進行自噬作用的話,促使它們啟動自行滅亡的機制,那豈不是殺滅它們的一道妙計?354Please respect copyright.PENANApA2UCzrkyU
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很遺憾地,各款癌細胞對於自噬作用的依賴及抗性均有所不同,難以就此單一針對自噬作用來消滅癌細胞。354Please respect copyright.PENANAnzb0PuAkK8
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暫時較為統一的發現是,大多數的胰臟癌細胞均非常依賴自噬作用來維持自己的生長速度。354Please respect copyright.PENANAL43g5bMcVf
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在實驗室細胞模型及老鼠實驗中,若果對胰臟癌細胞使用抑制自噬作用的藥物,不但改變它們的新陳代謝,且可減慢癌細胞的生長速度,非常之有潛質成為對抗胰臟癌的其中一手段。354Please respect copyright.PENANAGsDsATY8i1
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。354Please respect copyright.PENANAIrONBMkSQU
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc354Please respect copyright.PENANAzAmZgqgxf9
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。354Please respect copyright.PENANAD90Xrl5lq0
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Link:354Please respect copyright.PENANAeKDo0Wgx0F
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio354Please respect copyright.PENANAUsa6Vv4hqr
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除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。354Please respect copyright.PENANAtNcRwyN68t
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Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070934/354Please respect copyright.PENANAwzkUf4BdtY
Ref2:https://cancerres.aacrjournals.org/content/66/19/9349.long
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