肌肉大概佔據身體重量的40%。275Please respect copyright.PENANA8X6ua3UCiP
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踏入50歲後,平均每10年就會有15-30%的肌肉流失。275Please respect copyright.PENANAk2S7o7bLS9
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(圖2)研究(Ref1)顯示老人家的肌肉裡頭,一隻名為15-PGDH的蛋白酶數量普遍地比年輕人為高。275Please respect copyright.PENANAGqQCQY3ead
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而15-PGDH其中一道作用就是負責將激素PGE2及PGD2分解成為其他物質。275Please respect copyright.PENANAQYtUyYexTb
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(圖3)而人類老化所出現的現象,老鼠亦能同樣發現得到。275Please respect copyright.PENANAnU92k7P2Ak
除肌肉外,年長老鼠的心、肝、脾、大腸及皮膚亦出現15-PGDH蛋白酶上升的現象。275Please respect copyright.PENANAMfSrMxzZM3
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當利用藥物或基因工程手段降低年老老鼠的15-PGDH數量的話,肌肉重量亦會有所提升。275Please respect copyright.PENANAsFrU8LdCMH
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相反,若強行在年輕老鼠肌肉裡頭強行表達15-PGDH的話,肌肉重量亦會有所下降。275Please respect copyright.PENANAD6yuuF6NJR
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這道研究展示出,只需對一隻蛋白酶作出針對性的抑制,便能夠達到控制肌肉重量及結構的奇效。275Please respect copyright.PENANAIbj2Z01I5V
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現時已有藥物可抑制15-PGDH,但對於人類肌肉影響的臨床研究則欠奉。275Please respect copyright.PENANA4W3g0I3k9p
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只不過的是,現今均普遍認為增加體內細胞NAD數量的話,便可舒緩甚至是扭轉細胞的老化現象。然而,15-PGDH卻需要NAD才能正常運作,這一方面所出現的矛盾則未能解釋得到。275Please respect copyright.PENANAm5bN6v6U1y
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。275Please respect copyright.PENANAoTJ82P3RiF
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc275Please respect copyright.PENANAO1fb4FXj33
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。275Please respect copyright.PENANAwYxvsEFykr
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Link:275Please respect copyright.PENANACk2REijufQ
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio275Please respect copyright.PENANAmwtGqLsS4y
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基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。275Please respect copyright.PENANAq8EU6yQbyO
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Ref1:https://science.sciencemag.org/content/371/6528/eabc8059275Please respect copyright.PENANAr3PZPh1VeJ